CTLA4 and cancer: With the advent of immune checkpoint inhibitors (ICIs), mainly antiprogrammed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) and anticytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) monoclonal antibodies have made great progress in the field of research related to certain types of cancer [28].