ACE2 and COVID-19: Hence, the purpose of this study is to assess the molecular dynamic effect of ACE2-s680 phosphorylation by metformin on the interaction with wild-type (WT) and different forms of COVID-19 mutations such as Delta (δ), omicron and gamma (γ) as well as the SARS-CoV-2 receptor ACE2′s control of B0AT1.