In the early stage of sepsis, the body’s innate immune system first recognizes the pathogen-associated molecular patterns (PAMPs) after the pathogen has invaded, causing the release of a series of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1) and interleukin-6 (IL-6). The gene discussed is TNF; the disease is Sepsis.