VEGFA and head and neck squamous cell carcinoma: To surmount these issues, Lecaros (39) employed lipid-calcium-phosphate nanoparticles (LCP-NPs) to transport VEGF siRNA, and noted that photodynamic therapy (PDT) in combination with LCP-NPs-VEGF siRNA exhibited effective anti-tumor effects in HNSCC by impeding angiogenesis.