IL4 and allergic disease: Recent evidence suggested that specific microbes and microbial lysates may enhance the production of type 1 anti-inflammatory cytokines like IL-10 and IFN-γ, while inhibiting the overexpression of type 2 inflammatory factors like IL-4, IL-5, IL-13, and eotaxin, reversing the imbalance in type 1/type 2 immune response of allergic disease (46, 47).