CRP and Sepsis: To investigate the relationship between metabolites (Sphinganine and Mannose 6-phosphate) and the severity of sepsis, we analyzed the relative expression levels of metabolites in the healthy group and sepsis group, as well as the correlation between metabolites and Acute Physiology and Chronic Health Evaluation-II(APACHE-II) score, PCT (μg/L), white blood cell (WBC)×109/L, CRP(mg/L), and Interleukin-6(IL-6) (pg/ml).