The MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) lesion model in monkeys have also identified a very close correlation with 18F-DOPA uptake in the striatum, and multiple measures of parkinsonism, include symptoms on the Kurlan scale, striatal dopamine content, and markers of dopaminergic neurons, such as tyrosine hydroxylase (Blesa et al., 2012). The gene discussed is TH; the disease is Parkinson disease.