SERPINA3 and dementia: In a Martins et al.’s research, the ability of two Aβ-binding proteins—alpha-1-antichymotrypsin and C4b-binding protein alpha chains—was analyzed to validate exosome levels in patients by using antibody-based methods, indicating significant correlations between alpha-1-antichymotrypsin exosomal concentrations and mini-mental state examination scores and clinical dementia rating scores, indicators of cognitive alterations.