Moreover, ARNT is a TF of basic helix-loop-helix/per-arnt-sim (PAS) family members, and predominantly heterodimerizes with the aryl hydrocarbon receptor (AHR) or hypoxia-inducible factor-1 alpha (HIF-1α), which has been linked to PCa angiogenesis (Fritz, et al., 2008). Here, TF is linked to posterior cortical atrophy.