In addition, Sur et al. deciphered EGCG could restrain the tumorigenesis of HCC through shrinking the proportion of hepatocyte progenitor cells or CSCs, and modulating Wnt and hedgehog signaling pathways, in which the downregulated β-catenin, cyclinD1, c-Myc and EGFR but upregulated E-cadherin were detected (Sur et al., 2016). This evidence concerns the gene EGFR and hepatocellular carcinoma.