More narrowly, EGCG plays the prominent regulatory roles in a series of apoptosis-related signaling molecules in hepatoma cells, including upregulating the expression of p53, Bax, caspase-9, and caspase-3, downregulating the expression of NF-κB, survivin, and BCL2 apoptosis regulator (Bcl-2), and promoting the release of cytochrome c (Zhang et al., 2015; Yang H. et al., 2019; Sabry et al., 2019). This evidence concerns the gene CASP3 and hepatocellular carcinoma.