CD274 and neoplasm: All-trans retinoic acid (ATRA) can be loaded onto PLGA-PEG and then modified with PD-L1 antibody to prepare ATRA- Targeted α-t- FU-PLGA NPs (Srivastava et al., 2019), glutathione (GSH)-sensitive and folic acid (FA)-targeted paclitaxel-loaded NPs (FA-PEG-SS-PCL@PTX, FA-NPs) (Fan et al., 2020a), cRGD targeted polycarbonate (PCA) copolymer-based NPs (NanoPCA) loaded with DOX (NanoPCA-cRGD) (Yunxia et al., 2018) have been proved to have a good targeting effect, which can precisely release and enhance antitumor efficacy of diverse anti-tumor drugs.