KCNA1 and episodic ataxia type 1: To examine the role of neuron-type specific ionic current environments on the impact of altered ion currents properties on firing behavior, we performed those as follows: (1) firing responses were characterized with rheobase and ΔAUC, (2) a set of neuronal models was used, and properties of channels common across models were altered systematically one at a time, and (3) the effects of a set of episodic ataxia type 1 associated KCNA1 mutations on firing was then examined across different neuronal models with different ionic current environments.