In this study, we therefore investigated how the outcome of ionic current kinetic changes on firing depends on neuronal cell type, i.e., on the composition of ionic currents, by (1) characterizing firing responses with two measures, (2) simulating the response of a repertoire of different neuronal models to changes in single current parameters, and (3) bringing more complex changes in this case as they were observed for specific KCNA1 mutations that are associated with episodic ataxia type 1 (39, 41, 42). Here, KCNA1 is linked to episodic ataxia type 1.