Furthermore, statistical interactions were found between three SNPs (IL1A rs1609682, HABP2 rs7923349 and ITGA2 rs1991013) and carotid atherosclerosis by GMDR analysis, and the high-risk interactive genotypes in the three SNPs were significantly associated with a higher risk for carotid atherosclerosis. The gene discussed is ITGA2; the disease is carotid atherosclerosis.