The results exhibited that the high-risk interactive genotypes in IL1A rs1609682, ITGA2 rs1991013, and HABP2 rs7923349 were independently associated with a higher risk for carotid atherosclerosis after adjusting covariates (OR, 2.08, 95% CI: 1.257–5.980, P < 0.001, Table 5). This evidence concerns the gene IL1A and carotid atherosclerosis.