Entry into the CNS by coronavirus has been described through hematogenous or retrograde neuronal route, demonstrating the neurotropic and neuroinvasive capabilities of this pathogen.18 These statements corroborate with the finding of SARS-CoV viral particles in patients’ cerebrospinal fluid.19 The role of angiotensin-converting enzyme-2 (ACE-2) receptors has also been explored as an explanation for multi-organ involvement of the viral infection. This evidence concerns the gene ACE2 and viral infectious disease.