PSEN1 and Mental deterioration: Though ADAD‐causing PSEN1 variants are highly penetrant, there is striking heterogeneity in the observed age of symptom onset (Lippa et al., 2000; Ryan et al., 2016; Ryman et al., 2014; Wegiel et al., 1998), biomarker trajectories (Klunk et al., 2007), and cognitive decline (Ryan et al., 2016; Ryan & Rossor, 2010; Tang et al., 2016) across individuals with different PSEN1 variants.