We reintroduced the 12 genes, CAV2, PHLDA1, DUSP23, VDAC3, DSG2, SPINT2, SPATS2L, IGFBP3, CD9, ALCAM, PRSS23, CDKN2A, constructed as Neoadjuvant Chemotherapy Score into the single cell sequencing data of LUAD and ESCC patients before and after neoadjuvant therapy as well as the CCLE database. This evidence concerns the gene CAV2 and esophageal squamous cell carcinoma.