Intracellularly, activated CD226 aggregates lymphocyte function-associated antigen 1 (LFA-1) to conformationally change intracellular adhesion molecule 1 (ICAM-1), which recruits Fyn and then drives activation of the Akt signaling pathway to promote NK/T cell-mediated tumor cytotoxicity [27, 41, 42]. This evidence concerns the gene CD226 and neoplasm.