Treatment-related adverse events (TRAEs) occurred in 56% of patients undergoing the monotherapy and 62% of patients taking the combination therapy in part A, and 56% and 70% of patients with anti-PD-1/PD-L1-refractory NSCLC in part B. Common TRAEs were pruritus, fatigue, rash, and hypoalbuminemia. Here, CD274 is linked to non-small cell lung carcinoma.