INS and obesity due to melanocortin 4 receptor deficiency: Physical exercise programs lasting 4–12 weeks, or sessions of 60 min each, or involving a total exercise time of at least 1,500 min were effective in improving cardiometabolic and vascular parameters (lipids, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance [HOMA-IR], intrahepatic fat, systolic blood pressure, and carotid intima-media thickness) in children with obesity [75].