However, the molecular mechanism of the association between periodontitis and systemic diseases still needs further study.α-Klotho protein, a multifunctional protein, was first found as an anti-aging protein [9], and later was found to have important functions in anti-oxidative stress, anti-inflammation, regulation of calcium and phosphorus balance, regulation of tissue metabolism, and anti-apoptosis [10, 11]. The gene discussed is KL; the disease is periodontitis.