EZH2 and lung adenocarcinoma: Studies have demonstrated that TFAP2A increases EZH2 expression by perturbing the activity of the NuRD complex to enhance hyperacetylation of the EZH2 promoter region [13] and transcriptionally activate inositol 1,4,5-trisphosphate 3-kinase (ITPKA) and keratin 16 in lung adenocarcinoma (LUAD) [40, 41].