TFAP2E, on the other hand, perturbs the Wnt/β-catenin signaling by transcriptionally inhibiting the expression of dickkopf Wnt signaling pathway inhibitor 4 (DKK4), an antagonist of Wnt signaling that occupies the Wnt coreceptor, in colorectal cancer [10, 63, 64]. The gene discussed is DKK4; the disease is colorectal cancer.