For example, miR-200a targets TFAP2C mRNA [163], miR-200b suppresses TFAP2A expression in cholangiocarcinoma [36], miR-3960 suppresses TFAP2A mRNA in the pancreatic cancer [164], and miR-27a inhibits TFAP2B mRNA in HCC [55]. This evidence concerns the gene TFAP2B and hepatocellular carcinoma.