CD8A and neoplasm: As illustrated in Fig. 1B, 2-BP/CPT-PLNs could efficiently accumulate in tumor sites through blood circulation, boost CPT and 2-BP release with the help of intracellular high-level GSH after their entrance into tumor cells, upregulate cytotoxic CD8+ T cells infiltration via reinforcing ICD with CPT chemosensitization, and enable the replaced ICB and improved antitumor immune killing capacity of cytotoxic T cells via targeting PD-L1 degradation and regulating cytokines in tumor sites.