Alistipes indistinctus may help in the correct folding of proteins in endoplasmic reticulum for the sake of CRC cells and promote further progression by alleviating ER stress, which may be correlated to the increased PERK expression and activation of its downstream UPR by Alistipes indistinctus, but it still requires further experimental exploration. Here, EIF2AK3 is linked to colorectal carcinoma.