Liu et al. have showed that a significant decrease in traditional beneficial bacteria such as Lactobacillus and Bifidobacterium and a significant increase in oncogenic bacteria such as Enterobacteriaceae and Fusobacterium nucleatum in CRC patients, which tested that endotoxin (LPS), D- In addition, elevated levels of endotoxin (LPS), D-lactate and diamine oxidase (DAO) were confirmed to be associated with dysregulated fecal microbiota and intestinal mucosal barrier dysfunction in early CRC patients [9]. This evidence concerns the gene AOC1 and colorectal carcinoma.