CDKN1A and colorectal carcinoma: Metabolites of the intestinal microbiota can induce oncogenic stress responses, such as the transition growth of Porphyromonas secretes butyrate analogs that increase the expression of senescence-inducing genes (p16INK4a and p21Cip1/Waf1) and SASP factor genes (IL-1 and IL-6), accelerating cellular senescence, leading to increased DNA damage and p53 phosphorylation formation, which induces the development of CRC [5].