Subsequently, by exploring the relationship among the CRC progression-associated differential intestinal microbiome, immune infiltrating cells and immune-related genes, we did find that Alistipes genus had a remarkable positive correlation with mast cells (Fig. 4C), amidst which, Alistipes indistinctus manifested observable positive correlation with immune activators IL-6 and IL-6R. This evidence concerns the gene IL6R and colorectal carcinoma.