Therefore, our speculation is that Alistipes indistinctus is conductive to the correct folding of proteins in the ER of CRC cells, thereby reducing ER stress and facilitating the survival and progression of CRC, which may be on account of high expression of PERK and activation of downstream UPR boosted by Alistipes indistinctus. This evidence concerns the gene EIF2AK3 and colorectal carcinoma.