After co-culture with Proteus vulgaris and Proteus mirabilis, SNAI1 and VIM gene expressions had changed significantly in human colon cancer cell line Caco2, which are related to epithelial mesenchymal transformation, thus it was suggested that Proteus may be correlated with the epithelial mesenchymal transformation of CRC [21]. The gene discussed is SNAI1; the disease is colorectal carcinoma.