It is noteworthy that a research observed both elevated abundance of Alistipes in intestinal microbiome and myocardial PERK expression in diabetic cardiomyopathy models of mice, and after drug intervention, the expression levels of both declined [67], so it is highly likely that there is a positive correlation between Alistipes abundance and PERK expression. Here, EIF2AK3 is linked to diabetic cardiomyopathy.