Next, we analyzed the non-linear relationship between SUA with anemia and found that the smooth curve fitting between SUA and anemia was U-shaped (Fig. 1) after full adjustment for marital status, educational level, gender, age, smoking status, alcohol use, race, BMI, hypertension, diabetes mellitus, congestive heart failure, coronary heart disease, vitamin B12, RBC folate, total cholesterol, white blood cells, platelets, albumin, serum iron, and eGFR. The gene discussed is ALB; the disease is anemia.