KEGG pathway analysis showed that NEDD4 members participated in the regulation of multiple pathways including Akt, p53, autophagy and apoptosis (Fig. 3D) (Table S6), which were further visualized in Fig. 3E. In addition, the correlations between NEDD4 members and different pathways in various types of cancers were summarized in Fig. 3F. The gene discussed is AKT1; the disease is cancer.