PRF1 and hepatocellular carcinoma: On the other hand, as shown in Fig. 11F, overlapping genes were enriched in the spleen, blood, and bone marrow (CD56 + NK cells, MOLT4, CD14 + monocytes, and BDCA4 + dendritic cells), additional evidence for an immunomodulatory role of PRF1 in the pathogenesis of HCC is provided.