In hepatocellular carcinoma, HSP90AA1 promotes the growth of HCC cells by enhancing glycolysis and proliferation and reducing apoptosis through pyruvate kinase M2 (PKM2) [40].Studying the characteristics of ICDs in HCC will improve our knowledge of tumor aggressiveness and help develop more individualized and accurate immunotherapy protocols. The gene discussed is HSP90AA1; the disease is neoplasm.