In hepatocellular carcinoma, HSP90AA1 promotes the growth of HCC cells by enhancing glycolysis and proliferation and reducing apoptosis through pyruvate kinase M2 (PKM2) [40].Studying the characteristics of ICDs in HCC will improve our knowledge of tumor aggressiveness and help develop more individualized and accurate immunotherapy protocols. This evidence concerns the gene PKM and hepatocellular carcinoma.