In term of region, high expression of Gal-3 is significantly related to DN risk (SMD: 0.73; 95% CI: 0.58 to 0.87 for Asian; SMD: 0.79; 95% CI: 0.48 to 1.10 for Europe; SMD: 3.15; 95% CI: 2.73 to 3.56 for Africa) (Table 2). This evidence concerns the gene LGALS3 and liver dysplastic nodule.