Through unbiased KEGG pathway analysis of DEGs between Fga−/− and WT plasma-stimulated microglia, we identified the 12 top pathways induced by fibrinogen, including ROS (for example, Hmox1, Cox7a2, Slc25a5), COVID-19 (for example, Ccl12, Rps8, Rpl35) and AD (for example, Atp5e, Psmd2, Tubb5) (Fig. 1e,g). This evidence concerns the gene ATP5F1E and Alzheimer disease.