HMOX1 and metabolic dysfunction-associated steatohepatitis: The goal of the current study was to evaluate Nrf2/HO-1 and TLR4/NF-kB signaling pathways, as well as identify the dysbiosis in the gut microbiome that was associated with experimentally induced NASH, in order to investigate the potential therapeutic effects of citicoline either alone or in combination with Lactobacillus in experimentally induced NASH.