In the multi-regression model adjusted by age, sex, race, hypertension, hyperlipidemia, obesity, insulin status, and smoking history, HbA1c only showed a significant relationship with the AI of FAZ perimeter (beta = 0.007 [95% CI: 0.001, 0.013], p = 0.02) and AI of FAZ circularity (beta = 0.002 [95% CI: 0.000, 0.004], p = 0.022). The gene discussed is INS; the disease is hyperlipidemia.