GSR and cancer: Therefore, SelSA-1 mediated alteration in both enzymatic and non-enzymatic markers of oxidative stress was evaluated as a plausible key event behind the anti-cancer mechanism of SelSA-1 Fig. 5a–i, depicts AOM/DSS group induced enhanced cellular oxidative stress in terms of decreased activities of antioxidant activities GPx, GR along with a concomitant increase (p ≤ 0.05) in levels of total GST, total ROS, LPO, protein carbonyls and NO when compared to the Control and Vehicle group (Fig. 5).