The overexpression of LOHAN1, as well as of another driver lncRNA, LOHAN2 (LncRNA Oncogene in Head and Neck cancer—ENSG00000258779.2; RP11-140I24), increased tumorigenicity in head and neck (HN) cells, as measured by colony-forming potential (Fig. 4b, c), supporting the notion that some lncRNAs have a cell-type-specific activity. Here, PWRN1 is linked to head and neck cancer.