Consistent with analyses of the whole cohort, the relative frequency of IGHV genes by grouping per isotype (Fig. 4e) showed IgG1 and IgG2 to be associated with different IGHV genes in blood and tumor, and IgM to be associated with some IGHV genes in both blood and tumor, and others in tumor only. This evidence concerns the gene CD40LG and neoplasm.