Even though the SLC2A4 lead variant (rs117643180) was associated with an increased risk of T2D at nominal significance (beta = 0.046, SE = 0.015, P = 0.0018, N = 1,041,200, OR = 1.047) 26, this was the only post-challenge insulin resistance locus identified in European ancestry cohorts without evidence of a shared signal with T2D using formal colocalisation testing. Here, INS is linked to type 2 diabetes mellitus.