rs117643180 was associated with post-challenge insulin resistance and was previously reported to be associated with higher 2 h glucose (Beta = 0.19, SE = 0.025, P = 7.31x10-14, N = 38,302)3 but not fasting insulin (P = 0.22)3 or fasting glucose (P = 0.14)3 suggesting the effect of this locus is specific to the postprandial state (Figure 2). This evidence concerns the gene INS and Insulin resistance.