Univariate analyses identified GPR176 (hazard ratio (HR) = 1.83, P < 0.001), residual tumor (HR = 3.40, P < 0.001), Stage (HR = 1.84, P = 0.001), M stage (HR = 2.33, P = 0.004), N stage (HR = 1.57, P = 0.007), T stage (HR = 1.65, P = 0.018) and age (HR = 1.60, P = 0.007) were all significantly associated with OS in GC patients (see Supplementary Fig. S1a online, Table 1). Here, GPR176 is linked to neoplasm.