GPR176 and head and neck squamous cell carcinoma: As shown in Fig. 1a, GPR176 expression levels were significantly different in Breast invasive carcinoma (BRCA), Esophageal carcinoma (ESCA), Head and Neck squamous cell carcinoma (HNSC), Kidney Chromophobe (KICH), Kidney renal clear cell carcinoma (KIRC), Kidney renal papillary cell carcinoma (KIRP), STAD, and Uterine Corpus Endometrial Carcinoma (UCEC), suggesting an essential role in cancer.