NFE2L2 and multiple sclerosis: Nfe2l2 upregulation was similar between astrocytes from GFAP-Nrf2 mice (fold change 2.3 versus wildtype control) and multiple sclerosis astrocytes (fold change 1.8 versus healthy control) (IPA Analysis Match19,29), indicating a disease-relevant modulation of astrocytic Nrf2 activation in the mice.