4MOSC1 and 4MOSC2 cells were derived from 4NQO-induced tongue tumors isolated from female C57BL/6 mice.23 Control vectors (Vector) and pcDNA3.1/LIMP-2 plasmid vectors (OE-LIMP-2) were used to establish LIMP-2-overexpressing 4MOSC1 cells, while LIMP-2-targeting shRNA (shLIMP-2) or corresponding controls (shNC) were introduced into 4MOSC2 and SCC7 cells with relatively high endogenous LIMP-2 expression (Fig. S3a, b). Here, SCARB2 is linked to tongue neoplasm.