Recently, evidence has accumulated that targeting autophagy effectively counteracts the aggressiveness of CSCs in HNSCC.13 To clarify the role of autophagy in the LIMP-2-induced malignant phenotype of HNSCC, we inhibited autophagy in LIMP-2-overexpressing 4MOSC1 cells with CQ. The gene discussed is SCARB2; the disease is head and neck squamous cell carcinoma.