Our previous studies demonstrated that interference with CMTM6 inhibits the CSC properties of HNSCC and the TGF-β-induced EMT process by regulating the Wnt pathway.36 These results are encouraging and suggest that the classical Wnt/β-catenin pathway determines the differentiation fate and self-renewal potential of CSCs. Here, TGFB1 is linked to head and neck squamous cell carcinoma.