Past studies have found that lack of LIMP-2 but not LAMP-1 leads to impaired late endosome-lysosome fusion with phagosomes in mouse macrophages and therefore increased susceptibility to Listeria monocytogenes infection.32 In addition, mutations resulting in a functional deficiency of LIMP-2 did not affect lysosome formation but resulted in the inability of B lymphocytes to process autophagosomes.33 This implies a potential role of LIMP-2 in promoting the fusion of autophagosomes and lysosomes. The gene discussed is SCARB2; the disease is listeriosis.