Tissue specific Tgfbr1/Pten 2cKO mice, a spontaneously developed tumor model, exhibit many of the same biochemical changes as human HNSCC.22 The results showed that LIMP-2 expression was obviously elevated in Tgfbr1/Pten 2cKO HNSCC tissues compared with normal oral mucosal tissues (Fig. 2j, k). The gene discussed is TGFBR1; the disease is head and neck squamous cell carcinoma.