PRF1 and neoplasm: Furthermore, dLN B cells from tumor-bearing mice treated with GSK alone or along with FGK also showed a significantly reduced ability to inhibit IFNγ production by CD8 T cells (regardless of whether CD8 T cells were cultured with or without CD4+CD25− T cells; Supplementary Fig. S4a–c), and the production of perforin and granzyme B by CD8 T cells (Supplementary Fig. S4d–f), compared to those from tumor-bearing mice treated with Rat IgG or FGK.