Moreover, although increased frequency (Fig. 3f), proliferation (Supplementary Fig. S6b) and IL-10 secretion (Fig. 3g) of CD24hiIgDlo/−CD38lo Bregs in dLNs were detected in tumor-bearing mice treated with FGK compared to the controls treated with Rat IgG, the levels were significantly lower in mice treated with FGK plus GSK. This evidence concerns the gene IL10 and neoplasm.