Compared to naïve mice, the frequency (Fig. 3f), proliferation (Supplementary Fig. S6b) and IL-10 secretion (Fig. 3g) of CD24hiIgDlo/−CD38lo Bregs in dLNs (similar to naïve mouse LNs, dLNs from tumor-bearing mice also lacked CD24hiIgDlo/−CD38hi Bregs; Supplementary Fig. S7) were significantly elevated in tumor-bearing mice treated with Rat IgG, but not those treated with GSK. Here, IL10 is linked to neoplasm.