Compared to B cells from naïve mice that had a moderate inhibitory effect, significantly stronger inhibition of CD4 T cell IFNγ production was induced by B cells from tumor-bearing mice (Rat IgG-treated controls), which was further enhanced by FGK treatment (Fig. 1f), indicating that tumor formation and CD40 agonist may augment immunosuppressive B cells. Here, CD40 is linked to neoplasm.