Compared with IgG treatment, NK-cell depletion did not alter the inhibitory effect of the combination therapy, CD4+ T-cell depletion affected tumor growth more significantly than CD8+ T-cell depletion, whereas co-depletion of CD4+ T cells and CD8+ T cells completely abolished the antitumor effect of the combination therapy (Fig. 1l). This evidence concerns the gene CD4 and neoplasm.