NCOA3 and lung cancer: In addition, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB), an enzyme that regulates the interconversion of fructose-2,6-bisphosphate and fructose-6-phosphate, directly phosphorylates the steroid receptor coactivator-3, which further promotes the growth and metastasis of lung cancer in a preclinical model46.