C3a-C3aR-PI3K-AKT signaling also induces cancer-associated fibroblasts to secrete pro-metastatic cytokines and to express extracellular matrix components in breast cancer [23] and modulates tumor-associated macrophages to repress the antitumor immunity of PD-L1 antibody [43]. The gene discussed is AKT1; the disease is breast carcinoma.