In addition, we overexpressed kshv-miR-K12-1-5p using rAAV in transverse aortic constriction (TAC)-induced heart failure model and found that kshv-miR-K12-1-5p showed no effect on cardiac function in TAC-induced heart failure mice on the condition that IFNβ level was unchanged (Supplementary Fig. 19 and Supplementary Table 13). Here, IFNB1 is linked to heart failure.