HRT alone decreased the tumor-associated macrophages (TAMs, CD45+CD11b+F4/80+) phenotype among CD45+ cells, which was further decreased by adding anti-SIRPα (P = 0.0004 for HRT vs. Iso control, P = 0.0308 for anti-SIRPα + HRT vs. HRT; Fig. 3B). This evidence concerns the gene SIRPA and neoplasm.