Nonetheless, the expression of CSF1R, MRC1, and FN1 exhibited a significant reduction following SC-43 treatment (Fig. 7D), implying that SC-43 may inhibit the CSF1R/STAT3 signaling pathway and diminish the expression of fibrotic genes within macrophages in vivo during the pulmonary fibrosis progression. Here, STAT3 is linked to pulmonary fibrosis.