ApoE localizes with high-molecular weight Aβ oligomers in the TBS-soluble fraction of human AD brain (28), and ApoE co-deposits with amyloid plaques (29), suggesting that ApoE and Aβ also co-localize at later stages of AD, but whether ApoE and APP/Aβ are intersecting at an intracellular level remains less clear. This evidence concerns the gene APOE and Alzheimer disease.