While we show that pSTAT1 depends on UL138 and USP1 at late times during infection in fibroblasts (Figs 2 and 3), we were surprised that neither total or phosphorylated levels of TBK1 were affected by UL138 or USP1 as a possible mechanism to sustain pSTAT1 (Fig 4). The gene discussed is USP1; the disease is infection.