CARD8 and infection: Based on our results and the finding that FcγR-mediated uptake of SARS-CoV-2 virions into monocytes leads to abortive infection [37], we speculate that CARD8-dependent pyroptosis contributes to the poor permissiveness of myeloid cells for SARS-CoV-2 [49], wherein the myeloid compartment may not substantially contribute to viral load but likely impacts immunopathology via inflammasome-driven inflammation [50,51].