CRP and Thrombocytopenia: At baseline, a base excess <-10 mmol/L was documented in 352 of 1,492 with results available (23.6%), lactate >2 mmol in 1,034/1,283 (80.6%), raised CRP >10 mg/L in 1,306/2,286 (57.1%), abnormal white blood cell count (<4 or >20 × 109 cells/L) in 875/2,800 (31.3%), and thrombocytopenia (<150 × 109 cells/L) in 619/2,776 (22.3%) (S4 Table).