Interestingly, several antibody features were associated with worse outcomes in patients hospitalized with influenza A. Higher levels of HA-specific FcγR dimer–binding antibody and NK cell activation were associated with poorer clinical outcomes in patients with severe A/H1N1 influenza, indicating that the immunopathological or inflammatory effects of Fc-functional antibodies may outweigh their protective effects in this instance. The gene discussed is FCGR2A; the disease is influenza.