When IR occurs, the phosphorylation pathway of phosphatidylinositol kinase/protein kinase B (PI3K/AKT) is drastically blocked [10], and endothelial cells become dysfunctional due to the lack of endothelial nitric oxide synthase (eNOS), thereby promoting the occurrence of atherosclerosis (AS) [11–13]. The gene discussed is AKT1; the disease is atherosclerosis.