Of the significant variables identified in the univariate analysis (Table S4), a 10-year age increase; history of diabetes, CVD, cerebrovascular disease, or peripheral vascular disease (PVD); 5 mL/min/1.73 m2 eGFR decrease; 5 g/L serum albumin decrease; 0.1 mmol/L phosphate increase; and doubling the urinary protein:creatinine ratio significantly increased risk for any CV event or ACM in the final joint model (Table 2). This evidence concerns the gene ALB and peripheral vascular disease.