Of the variables that were statistically significant in the univariate analysis (Table S7), 10-year age increase; history of diabetes, CVD, cerebrovascular disease, or PVD; 5 mL/min/1.73 m2 eGFR decrease; 5 g/L serum albumin decrease; and 0.1 mmol/L phosphate increase were significantly associated with higher risk of MACE in the joint final model (Table S8). The gene discussed is ALB; the disease is diabetes mellitus.