Adverse remodeling post-myocardial infarction is hallmarkedbythe phenotypic change of cardiac fibroblasts (CFs) into myofibroblasts(MyoFs) and over-deposition of the fibrotic extracellular matrix (ECM)mainly composed by fibronectin and collagens, with the loss of tissueanisotropy and tissue stiffening. Here, FN1 is linked to myocardial infarction.